The Science Behind Nutrition, Polysaccharides & Alzheimer’s Recovery

In this powerful and enlightening episode, clinical researcher and nutritional pioneer Dr. John E. Lewis shares the science behind polysaccharides, plant-based sugar molecules with remarkable potential to support brain health, immune resilience, and chronic disease recovery—especially Alzheimer’s disease.

Known for his groundbreaking 12-month clinical trial using Aloe Polymannose Multinutrient Complex (APMC) in Alzheimer’s patients, Dr. Lewis reveals what many mainstream approaches overlook: nature-based compounds may offer not just symptom relief, but real neuroprotective change.

Dr. John Lewis’s work invites us all to rethink what “natural” can mean in serious disease management. His Alzheimer’s trial isn’t just a single study. It’s a stepping stone toward a more integrated, nutrition-centred paradigm for the brain. And with him back for more episodes, there’s much more to unpack—stay curious.

What Is APMC—and Why Is It Revolutionary?

In a peer-reviewed clinical trial published in The Journal of Alzheimer’s Disease, Dr. Lewis and his team tested APMC on adults with moderate Alzheimer’s. After one year of supplementation:

• 46% achieved clinically significant improvement in cognitive scores

• Blood biomarkers showed decreased inflammation (TNF‑α, IL‑2, IL‑4, VEGF)

• Participants saw immune modulation and improvements in daily function

The compound—rich in acemannan (a polysaccharide found in aloe vera)—was linked to regeneration in brain and immune systems alike.

“When the body is supported nutritionally, the brain can often do more than we’ve believed possible.” – Dr. John Lewis

Read more about this study here.

What Are Polysaccharides?

Polysaccharides are long-chain carbohydrates found in nature—like in aloe vera, rice bran, and medicinal mushrooms. While often overshadowed by vitamins and minerals, they play a major role in:

• Immune modulation

• Neuroprotection

• Gut-brain communication

• Cellular regeneration

Recent reviews suggest they help support the microbiome, reduce neuroinflammation, and aid in mitochondrial health—key for degenerative brain conditions.

For more insights, check out these studies and articles:
🧬 The power of polysaccharides for brain health – Interview
🌿 MDPI review on natural sugar molecules and neuroprotection
🧠 Polysaccharides and the brain–gut axis – ScienceDirect

Don’t Miss His TEDx Talk

Dr. Lewis powerfully summarises his vision in his TEDxMiami Talk:
🔴 “The Future of Health is Here Today”

In it, he presents compelling evidence on how functional nutrition, not just pharmaceuticals, can lead us into a future of cognitive and physical vitality. He encourages a lifestyle approach where diet, movement, and select supplements are central to health span and longevity.

Candid, Inspiring, and Coming Back for More

What made this interview extra special was Dr. Lewis’s openness and humility. He didn’t claim to have found the cure, but passionately emphasised the need for rigorous research, daily health practice, and empowering individuals to take control of their wellbeing.

And here’s the best bit—he’s agreed to return for a follow-up episode, where we’ll dive deeper into:

• Stem cell regeneration

• Brain–gut connections

• Nutritional tools for viral immunity

• And more of his upcoming research

So stay tuned!

Final Thought:
Dr. Lewis’s, Dr Lewis Nutrition® reminds us that healing isn’t only found in a prescription bottle. Sometimes, it begins with a plant, a protocol, and a willingness to ask better questions. And that’s exactly what this episode offers.

Listen Now

🎧 Click here to listen to the episode
🌿 Explore Dr. Lewis’s research and products
🎥 Watch his TEDx Talk
📚 Read his Alzheimer’s study
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